Doctors on Hair Loss & Hair Transplant surgery.

I have heard that it is possible through gene therapy and biological methods to make straight here permanent curly. Do you know if this is on the market yet for cosmetic purposes and if so please can you provide contact details of the clinics.

There are many potential gene therapies being investigated now. One company in San Diego (which researchers do not name) is supposedly working on a cream to help regrow hair using gene therapy. They evidently are also working on one to turn grey hair back to its dark original color, and one to cause a “permanent permanent” (straight hair turned curly). These are a ways off from being released to the public, if they even prove to be effective.
If they do work, at least partially, they would then have to go through FDA approval, which may take years and cost tens of millions of dollars (although there would certainly be plenty of investors in a product that would cure baldness, for example).
Also, there are many ethical questions that are only now being raised regarding gene therapy. Some have to do with creating “cosmetic or aesthetic perfection” for those who can afford it, and creating an undedrclass of “cosmetically challenged” humans, who cannot.

Certainly no one is going to forbid someone from marketing a cure for baldness, or a “genetic permanent”; however, these possibilities are at this point just that: possibilities. The press tends to take these things and run with them, but they are often exaggerated and made to seem closer to mass consumption than they really are.

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I am 27 and first noticed that i had hair loss about 24..My dad also has hair loss so its should be caused by genetic. About 1 year ago,i already had very little hair . I have been using Minoxidil 5 %, and Propecia, and it helps to control the hair loss but recently i realize that there is excessive hair loss even though i use it faithfully. I tried other ways of different treatment but i dun see any results. I recently saw this product “provillus’,its main ingredient is saw palmetto. It is said that it is similar to propecia but it doesn’t affect your sex drive ,Is this true? Can you please advise me on what other methods can i try,i recently just bought a laser set,do you think it will be useful?

Hair Loss is a multi-factorial problem. This is probably why some people respond well to DHT inhibitors such as Propecia and why others do not respond as well. Some people respond well to Minoxidil or Rogaine, while others do not. We recommend treating your hair loss with as many options as possible to cover as many potential causes of hair loss as possible.

You can purchase saw palmetto over the counter in a health food store and take the pills each day. Saw palmetto is a DHT blocker. We recommend you use this.

We also recommend you shampoo with Nizoral Shampoo at least once a week. Leave the product on for 5 minutes prior to rinsing. The product is a topical agent so it needs skin contact to do its job. We also recommend Hair Cycle shampoo and conditioner 4 to 5 times per week. Again, leave this product on 5 minutes prior to rinsing. Hair Cycle is an anagen stimulator so it will help you keep the hair in the growing phase longer. This should help you prolong the life of your hair. Hair Cycle is also healthier for your scalp since it lacks sodium laurel sulfate, which is the agent creating lather in most shampoos. This lather is the equivalent to engine degreaser and it is not healthy.

Other products you might consider include topical spironolactone.

The laser comb is expensive, but should help. We are working on a less expensive model.

You might find that decreasing the dosage of your Propecia to three times a week on Monday, Wednesday, and Friday has less of an affect on your sex drive.

Please note that Rogaine Foam is a new version of topical minoxidil and seems to produce less skin irritation. It also is better absorbed and does not leave your hair oily or greasy the way most minoxidil solutions do.

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What is Maximum Medical therapy for hair loss?

People with hair loss, and certainly anyone even CONSIDERING hair transplant, may want to use a regimen of maximum medical therapy. This just means using a number of different medications that have different mechanisms of action to try to “cover all the bases”, so to speak. Attacking hair loss by targeting different aspects of the process is a way of using the synergy between various agents to maximize the effects.

Finasteride (Propecia and Proscar) is an agent that blocks the formation of dihydrotestosterone (DHT), a hormone that has been implicated in male pattern baldness (androgenic alopecia). This is a first line drug for men with thinning hair or balding. It is not beneficial for women; in fact, it can cause birth defects if a woman is exposed to the drug and gets pregnant. It has few side effects in men and has been used for about 25 years with a good safety record.

Minoxidil (Rogaine and many generic versions) is topical, or placed directly on the scalp. Side effects are few, and it has a synergy when used with finasteride. This may be used in men and women, and is considered by many to be the drug of choice in women with hair loss.

There is some evidence that an anti-fungal shampoo containing ketoconozol (Nizoral) may help slow hair loss. It can be used twice a week and has the added effect of decreasing dandruff and itching of the scalp. There are also a variety of over the counter preparations (Hair Cycle products) and internet-marketed preparations that are available. Many of these contain minoxidil and other ingredients. Some of these are topical androgen (male hormone) blockers; there is little scientific proof of their effectiveness, but many men swear by them, and they may work for some.

The most important thing one can do with these latter agents is read and read some more. Information from sources other than the manufacturers is likely to be more objective and may help one with informed decisions.

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Now that there is a genetic test to predict your hair loss, is it possible to simply wipe out this gene and thus put a halt to hair loss?

The genetic test is a test for a marker on the X chromosome that predicts hair loss. We do not know if this gene has anything to do with the cause of hair loss. Hair loss is multifactorial. This is probably why you see a few people who respond favorably to certain topical or oral medications while others don’t seem to respond at all. It is more probable that hair loss results from the interaction of multiple genes. It remain unknown what would happen should we alter a single gene. The consequences might actually be negative.

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I see on your website that you offer a Hairdx test, what is it and how is it helpful to prevent hair loss?

Hairdx is a genetic marker test to determine your risk for hair loss and to determine whether you might not loose your hair. The test evaluates a specific marker on the X chromosome. As you know, the X chromosome arises from the mother of the male. The marker is on the androgen receptor gene located on the X chromosome. Men who carry this gene variant are at a 60% risk of loosing their hair by age 40. Men with the less common genetic variant have a greater than 85% probability of not going bald before age 40. Ninety-five percent of bald men have the high risk androgen receptor variant.

It is known, however that androgenetic hair loss is polygenic in inheritance. One receives genes from both the mother and the father and it is felt that hair loss is not sex linked. This means that you can receive the risk for hair loss from either the mother or the father, but the specifics are still poorly understood. To date there are 4 major genes that determine your risk for hair loss, age of onset, eventual hair loss pattern, and rate of hair loss progression.

This test is only a prediction of future hair loss. It does not rule in or rule out the probability of future hair loss entirely. If you test positive, you should be evaluated for other signs of hair loss. These include miniaturization of the hair follicles and loss of hair shaft pigment. If you show signs at any point after testing positive for the marker, you might want to consider medical therapy such as Propecia or Minoxidil. You might also want to begin using Haircycle shampoo and conditioner to prolong the anagen duration, which is known to slow down the rate of hair loss progression. Instituting medical therapy at an earlier stage in life may limit the rate of your progression and the ultimate degree of loss you will suffer from.

We are happy to send a test kit to you if you like. The cost of the test is 149.00. This is the first diagnostic test to help you determine if hair loss may be in your future.

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